Research Scientist II, Discovery Research

Alexion Pharmaceuticals, Inc.
New Haven
Jan 25, 2018
Feb 22, 2018
Employer Type
Direct Employer
Employment Type
Full Time
Position Summary

The Research Scientist II contributes directly to the discovery of protein therapeutics for diseases caused by dysregulation of the complement system. The successful candidate will serve on cross-functional project teams and lead efforts to design, discover and optimize protein therapeutics. This will be accomplished through lab-based work and by managing collaborations with CROs and strategic partners.

Principal Responsibilities

* Apply understanding of disease-target associations, PK/PD relationships and protein engineering to design and optimize biologic therapeutics.

* Serve on project teams as the molecular biology lead for antibody discovery.

* Establish fit-for-purpose discovery cascades and perform laboratory research to discover and characterize therapeutics.

* Project timelines.

* Manage collaborations with CRO and industry partners.

* Prioritize tasks and coordinate efforts to deliver quality results under aggressive timelines

* Keep meticulous records and generate technical reports to support regulatory filings.

* Present concepts, results and conclusions internally and externally.

* Remain current on new advances in antibody discovery and complement biology through literature research and attendance at relevant scientific meetings.

* Evaluate and propose new targets/ indications for the portfolio.


* Ph.D. with 2-5 years' of relevant post-doctoral experience.

* Expertise in molecular biology, protein engineering and antibody discovery.

* Ability to formulate testable hypotheses, design experiments, analyze data, draw conclusions and plan next steps.

* Creativity, innovation and critical thinking.

* Ability to distill information from various sources, identify gaps and issues and propose solutions.

* Capacity to manage and prioritize multiple projects and to allocate effort and resource appropriately.

* Strong collaborative and interpersonal skills; excels in a team environment.

* Excellent communication skills.


* Ph.D. or equivalent combination of degree and professional experience in Pharmacology, Biochemistry, Chemical Engineering, Cell or Molecular Biology, Immunology or related field.

* LI-CS1

New Haven, CT, United States

No Selection

Alexion is a global biopharmaceutical company focused on developing and delivering life-transforming therapies for patients with devastating and rare disorders. Alexion developed and commercializes Soliris? (eculizumab), the first and only approved complement inhibitor to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), two life-threatening ultra-rare disorders. As the global leader in complement inhibition, Alexion is strengthening and broadening its portfolio of complement inhibitors, including evaluating potential indications for eculizumab in additional severe and ultra-rare disorders. Alexion's metabolic franchise includes two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare disorders, Strensiq? (asfotase alfa) to treat patients with hypophosphatasia (HPP) and Kanuma? (sebelipase alfa) to treat patients with lysosomal acid lipase deficiency (LAL-D). In addition, Alexion is advancing the most robust rare disease pipeline in the biotech industry, with highly innovative product candidates in multiple therapeutic areas.

As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Alexion, please visit or download our App for iPhones and Blackberries.

Alexion is an Equal Opportunity /Affirmative action employer SDL2017

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