Research Scientist I, Discovery Research CT, Molecular Engineering Gro

Alexion Pharmaceuticals, Inc.
New Haven
Jan 25, 2018
Feb 22, 2018
Employer Type
Direct Employer
Employment Type
Full Time
Position Summary

The Research Scientist I is an experienced bench scientist who contributes to the development of novel therapeutics that address dysregulation of the complement system. Primary responsibilities include conducting the laboratory research to discover, characterize and optimizes therapeutic antibodies and fusion proteins. The Research Scientist is also relied upon for the design and timely delivery of protein reagents required by teams to achieve their research objectives.

Principal Responsibilities

* Discovery and optimization of protein therapeutics; accomplished through hands-on laboratory work and managing CROs

* Participation in cross functional teams to deliver experimental data and serve as a molecular biology subject matter expert

* Characterization of the specificity and functional properties of novel protein therapeutics; assay development as necessary

* Plan and conduct experiments; manage workflow and project timelines

* Act as a single point of contact between project team leaders and the protein expression laboratories to ensure delivery of protein reagents

* Maintain detailed and accurate records

* Generate technical reports to support regulatory filings

* Present results at group and departmental meetings

* Remain current on new advances in antibody discovery and complement biology through literature research and attendance at relevant scientific meetings.


* Experience with state-of-the-art library-based antibody discovery technologies

* In depth understanding of antibody sequence analysis, humanization and affinity maturation

* Experience with characterizing antibody specificity

* Binding and ligand/receptor antagonism assays

* Proficient in protein expression, purification and characterization

* Ability to work independently and apply scientific principles to formulate hypotheses. Ability to design and conduct experiments that produce meaningful results

* Strong interpersonal skills and ability to thrive matrix research organization

* Capacity for independent research and interdisciplinary collaboration

* Highly organized with attention to detail

* Excellent communication skills


* PhD with 1-3 years' relevant experience. Highly qualified candidates with BS/MS and at least 6 years relevant experience will also be considered.

* LI-CS1

New Haven, CT, United States

No Selection

Alexion is a global biopharmaceutical company focused on developing and delivering life-transforming therapies for patients with devastating and rare disorders. Alexion developed and commercializes Soliris? (eculizumab), the first and only approved complement inhibitor to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), two life-threatening ultra-rare disorders. As the global leader in complement inhibition, Alexion is strengthening and broadening its portfolio of complement inhibitors, including evaluating potential indications for eculizumab in additional severe and ultra-rare disorders. Alexion's metabolic franchise includes two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare disorders, Strensiq? (asfotase alfa) to treat patients with hypophosphatasia (HPP) and Kanuma? (sebelipase alfa) to treat patients with lysosomal acid lipase deficiency (LAL-D). In addition, Alexion is advancing the most robust rare disease pipeline in the biotech industry, with highly innovative product candidates in multiple therapeutic areas.

As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Alexion, please visit or download our App for iPhones and Blackberries.

Alexion is an Equal Opportunity /Affirmative action employer SDL2017

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